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      唯尚立德成功为国内多个课题组所定制构建的基因工程动物已被应用于生命科学领域的一线研究,发表于Nature、Nature Biotechnology、 Nature Cell Biology、Nature Communications、Cell Research等多家国际著名学术期刊。

1、Efficient generation of mice carrying homozygous double-floxp alleies using the Cas9-Avidin/Biotin-donor DNA system. Cell Research, 2017 Apr; 27(4): 578-581(IF=14.812)

2、Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway. Youming Li, Chaohui Yu. BMJ(Gut 2017;0:1–12. doi:10.1136/gutjnl-2017-313778)

3、TALEN-mediated knockout of CCR5 confers protection against infection of human immunodeficiency virus. Zhang, Linqi. JAIDS Journal of Acquired Immune Deficiency Syndromes:Post Acceptance: October 03, 2016

4、Generation of TALEN-mediated FH knockout rat model. Zhenhe Suo. Oncotarget. 2016 Aug 19.

5、Generation of biallelic knock-out sheep via gene-editing and somatic cell nuclear transfer. Hong-Ye Zhao, Wen Wang and Hong-Jiang Wei. Scientific Reports. 2016; 6: 33675

6、Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology 2016;151:152 164.(IF=18.187)

7、TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Qi Zhou, Shihua Yang and Andy Peng Xiang. Cell Research (2016) 26:1048-1061. (IF=14.812)

8、Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations^]. Nature communications, 2015,6. (IF= 11.329)

9、Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration. Ying Jin and Guo-Tong Xu. Stem Cell Research & Therapy 2015 6:219

10、Simultaneous editing of three homoeoaileles in hexapioid bread wheat confers heritable resistance to powdery mildew[J]. Nature biotechnology, 2014, 32(9): 947-951. (IF=43.113)

11、Pc>doplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. BLOOD, 2014,124(24):3656-3665. (IF=11.841)

12、Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Lijun Xia. BLOOD, 4 DECEMBER 2014 x VOLUME 124, NUMBER 24(IF=11.841)

13、TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. Weizhi Ji. Cell Stem Cell 14, 323–328, March 6, 2014 Elsevier Inc. 323(IF= 22.387)

14、Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature, 2013, 502(7469):105-109. (IF=38.138)

15、Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Jing-Wei Xiong and Jianzhong Jeff Xi. Cell Research (2013) 23:465–472. (IF=14.812)

16、Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos[J]. Cell research, 2013,23(4): 465-472. (IF= 14.812) Targeted genome modification of crop plants using a CRISPR-Cas system[Jj. Nature biotechnology, 2013, 31(8): 686-688. (IF= 43.113)

17、Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Lijun Xia.3 october 2013| VOL 502 | NATURE| 1 0 5.(IF=38.138)

18、Clathrin and pho$phatidylin〇sit〇l-4, 5-bispho$phate regulate autophagic lysosome reformation(J]. Nature cell biology, 2012,14(9): 924-934. (IF= 18.699)

19、Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis[J]. Nature communications, 2011, 2: 554. (IF= 11.329)

20、Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. The Journal of Clinical Investigation, 2011,121(4):1657-1666.(IF=12.575)

21、Core 1-derived O-glycans are essential E-selectin ligands on neutrophils. PNAS, 2010,107(20):9204-9209. (IF=9.432)

22、Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs. Jianguo Zhao. SCIENTIFIC REPORTS | 4 :6926 |DOI:10.1038/srep06926

23、Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Feng Shao. Nature, 513, 237–241 .(IF=38.138)

24、Highly efficient CRISPRCas9mediated transgene knockin at the H11 locus in pigs. Kui Li. Scientific RepoRts | 5:14253 | DOi: 10.1038/srep14253